别名
|
JBTS6; MKS3; NPHP11; TMEM67; TNEM67;
|
Clonality
|
Monoclonal
|
存储缓冲液
|
Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% New type preservative N and 0.05% BSA.
|
免疫原
|
A synthetic peptide of human Meckelin
|
稀释度
|
WB 1:1000, IHC-P/IF-P 1:50, IF-ICC 1:200, FCM 1:50
|
参考分子量
|
112kDa
|
预测分子量
|
112kDa
|
运输及保存条件
|
20°C/1 year
|
Human Gene ID
|
91147
|
基因名称
|
TMEM67
|
蛋白名称
|
MKS3
|
宿主
|
Rabbit
|
同种型
|
LgG
|
组织表达
|
Widely expressed in adult and fetal tissues. Expressed at higher level in spinal cord.
|
细胞定位
|
Cell membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Cell projection
, cilium Cytoplasm, cytoskeleton, cilium basal body. Note=Localizes at the transition zone, a region between the basal b
ody and the ciliary axoneme (PubMed:22121117).
|
注意事项
|
Meckelin Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
|
功能
|
Required for ciliary structure and function. Part of the tectonic-like complex which is required for tissue-specific ciliog
enesis and may regulate ciliary membrane composition (By similarity). Involved in centrosome migration to the apical cell s
urface during early ciliogenesis. Involved in the regulation of cilia length and appropriate number through the control of
centrosome duplication. Required for cell branching morphology. Essential for endoplasmic reticulum-associated degradation
(ERAD) of surfactant protein C (SFTPC).
|