The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer
sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The
protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID,
is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid
hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction
with initiation factors and cofactors. This protein also acts as a metastasis suppressor. Several alternatively spliced
transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2012]
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