别名
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MMP 17; Mmp17; MT MMP4; MT-MMP 4; MT4 MMP; MT4-MMP; MT4MMP; MTMMP4;
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Clonality
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Monoclonal
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存储缓冲液
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Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% New type preservative N and 0.05% BSA.
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免疫原
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A synthetic peptide of human MT4-MMP
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稀释度
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WB 1:1000, IHC-P/IF-P 1:100, IF-ICC 1:20-1:100
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参考分子量
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63kDa
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预测分子量
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67kDa
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运输及保存条件
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20°C/1 year
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Human Gene ID
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4326
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基因名称
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MMP17
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蛋白名称
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MT4MMP
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宿主
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Rabbit
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同种型
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LgG
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组织表达
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Expressed in brain, leukocytes, colon, ovary testis and breast cancer. Expressed also in many transformed and non-\
transformed cell types
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细胞定位
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[Isoform Long]: Cell membrane; Lipid-anchor, GPI- anchor; Extracellular side. Secreted, extracellular space, extracellular
matrix
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注意事项
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MMP17 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
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功能
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Endopeptidase that degrades various components of the extracellular matrix, such as fibrin. May be involved in the activation
of membrane-bound precursors of growth factors or inflammatory mediators, such as tumor necrosis factor-alpha. May also be i
nvolved in tumoral process. Cleaves pro-TNF-alpha at the '74-Ala-|-Gln-75' site. Not obvious if able to proteolytically activ
ate progelatinase A. Does not hydrolyze collagen types I, II, III, IV and V, gelatin, fibronectin, laminin, decorin nor alpha
1-antitrypsin.
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