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Cyclophilin A (15Q13) Rabbit Monoclonal Antibody
A-DK11723
Cyclophilin A (15Q13) Rabbit Monoclonal Antibody
货号 纯度 规格 目录价 会员价 库存 数量 购买
A-DK11723-50µl 50µl 50µl ¥1200.00 登录查看
A-DK11723-100µl 100µl 100µl ¥2200.00 登录查看
产品详情

产品名称

Cyclophilin A (15Q13) Rabbit Monoclonal Antibody

英文名称

Cyclophilin A (15Q13) Rabbit Monoclonal Antibody

类别

抗原抗体

反应种属

Human,Mouse,Rat

应用

WB,IHC-P,IHC-F

别名

CyclophilinA; Cyclosporin A binding protein; CYPA; CYPH; Peptidyl-prolyl cis-trans isomerase A; Rotamase A; PPIase A; PPIA;

Peptidyl-prolyl cis-trans isomerase A;

Clonality

Monoclonal

存储缓冲液

Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% New type preservative N and 50% glycerol. Store at +4°C

short term. Store at -20°C long term. Avoid freeze / thaw cycle.

稀释度

WB 1:1000-1:2000,IHC-P/IHC-F 1:100-1:200

运输及保存条件

20°C/1 year

Human Gene ID

5478

预测分子量

18kDa

参考分子量

18kDa

蛋白名称

CYPA

基因名称

PPIA

宿主

Rabbit

同种型

LgG

细胞定位

Cytoplasm. Secreted. Nucleus Note=Secretion occurs in response to oxidative stress in vascular smooth muscle through a v

esicular secretory pathway that includes Rho GTPase signaling, actin remodeling, and myosin II activation

注意事项

Cyclophilin A Antibody is for research use only and not for use in diagnostic or therapeutic procedures.

功能

Catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (PubMed:, PubMed:20676357, Pu
bMed:21245143, PubMed:25678563, PubMed:21593166). Exerts a strong chemotactic effect on leukocytes partly through activatio
n of one of its membrane receptors BSG/CD147, initiating a signaling cascade that culminates in MAPK/ERK activation (PubMed
:11943775, PubMed:21245143). Activates endothelial cells (ECs) in a proinflammatory manner by stimulating activation of NF-
kappa-B and ERK, JNK and p38 MAP-kinases and by inducing expression of adhesion molecules including SELE and VCAM1 (PubMed:
15130913). Induces apoptosis in ECs by promoting the FOXO1-dependent expression of CCL2 and BCL2L11 which are involved in E
C chemotaxis and apoptosis (PubMed:31063815). In response to oxidative stress, initiates proapoptotic and antiapoptotic sig
naling in ECs via activation of NF-kappa-B and AKT1 and up-regulation of antiapoptotic protein BCL2 (PubMed:23180369). Nega
tively regulates MAP3K5/ASK1 kinase activity, autophosphorylation and oxidative stress-induced apoptosis mediated by MAP3K5
/ASK1 (PubMed:26095851). Necessary for the assembly of TARDBP in heterogeneous nuclear ribonucleoprotein (hnRNP) complexes
and regulates binding to RNA UG repeats and TARDBP-dependent expression of HDAC6, ATG7 and VCP which are involved in
clearance of protein aggregates (PubMed:25678563). Plays an important role in platelet activation and aggregation (By simi
larity). Regulates calcium mobilization and integrin ITGA2B:ITGB3 bidirectional signaling via increased ROS production as w
ell as by facilitating the interaction between integrin and the cell cytoskeleton (By similarity). Binds heparan sulfate gl
ycosaminoglycans (PubMed:11943775). Inhibits replication of influenza A virus (IAV) (PubMed:19207730). Inhibits ITCH/AIP4-m
ediated ubiquitination of matrix protein 1 (M1) of IAV by impairing the interaction of ITCH/AIP4 with M1, followed by the s
uppression of the nuclear export of M1, and finally reduction of the replication of IAV (PubMed:30328013, PubMed:22347431).

                         

Western blot analysis of Cyclophilin A expression in HepG2 cell lysate.

PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

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