|
产品名称 |
WIPI1 (5F14) Rabbit Monoclonal Antibody |
|
英文名称 |
WIPI1 (5F14) Rabbit Monoclonal Antibody |
|
类别 |
抗原抗体 |
|
反应种属 |
Human,Mouse,Rat |
|
应用 |
WB,IHC-P,IHC-F |
|
别名 |
ATG18; ATG18A; WIPI 1; WIPI-1; WIPI49; |
|
Clonality |
Monoclonal |
|
存储缓冲液 |
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% New type preservative N and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle. |
|
稀释度 |
WB 1:1000-1:2000,IHC-P/IHC-F 1:100-1:200 |
|
运输及保存条件 |
20°C/1 year |
|
Human Gene ID |
55062 |
|
预测分子量 |
49kDa |
|
参考分子量 |
48kDa |
|
蛋白名称 |
WIPI49 |
|
基因名称 |
WIPI1 |
|
宿主 |
Rabbit |
|
同种型 |
LgG |
|
组织表达 |
Ubiquitously expressed. Highly expressed in skeletal muscle, heart, testis, pancreas and placenta. Highly expressed in G361, Sk-mel-28, Sk-mel-13, WM852 and WM451 cells. Up-regulated in a variety of tumor tissues. |
|
细胞定位 |
Golgi apparatus, trans-Golgi network. Endosome. Cytoplasmic vesicle, clathrin-coated vesicle. Preautophagosomal structur e membrane; Peripheral membrane protein. Cytoplasm, cytoskeleton. Note=Trans elements of the Golgi and peripheral endoso mes. Dynamically cycles through these compartments and is susceptible to conditions that modulate membrane flux. Enriche d in clathrin-coated vesicles. Upon starvation-induced autophagy, accumulates at subcellular structures in the cytoplasm : enlarged vesicular and lasso-like structures, and large cup-shaped structures predominantly around the nucleus. Recrui tment to autophagic membranes is controlled by MTMR14. Labile microtubules specifically recruit markers of autophagosome formation like WIPI1, whereas mature autophagosomes may bind to stable microtubules |
|
注意事项 |
WIPI1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
|
功能 |
Component of the autophagy machinery that controls the major intracellular degradation process by which cytoplasmic materia |
 Rabbit Monoclonal Antibody.jpg)
Western blot analysis of WIPI1 expression in A375 cell lysate.
May play a role in autophagy. May regulate the trafficking of proteins involved in the mannose-6-phosphate receptor (MPR) recycling pathway.
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 Rabbit Monoclonal Antibody.jpg)
资料/datasheet
