别名
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NAD-dependent protein deacetylase sirtuin-3, 351-, Regulatory protein SIR2 homolog 3, SIR2-like protein 3, mSIR2L3, Sirt3, Sir2l3
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Clonality
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Polyclonal
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稀释度
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WB 1:64000
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预测分子量
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37kDa
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宿主
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Rabbit
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同种型
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IgG
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Human Gene ID
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NP_001120823.1;NP_001171275.1;NP_071878.2
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组织表达
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Strongly expressed in liver and kidney (PubMed:11056054). Expressed in skeletal muscles (at protein level) (PubMed:23283
301, PubMed:23835326). Weakly expressed in lung (PubMed:11056054).
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细胞定位
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[Isoform L]: Mitochondrion matrix
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背景介绍
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SIRT3 is a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are
characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been det
ermined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA
. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferas
e activity. The SIRT3 is included in class I of the sirtuin family.
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纯化
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Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein
A column, followed by peptide affinity purification.
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特异性
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This Sirt3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide betw
een 225-253 amino acids from the C-terminal region of Mouse Sirt3.
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