PACSIN1 Rabbit Polyclonal Antibody (N-term) - 上海抚生实业有限公司

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PACSIN1 Rabbit Polyclonal Antibody (N-term)

产品编号： A-DK14232

英文名称： PACSIN1 Rabbit Polyclonal Antibody (N-term)

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货号	纯度	规格	目录价	会员价	库存	数量	购买
A-DK14232-50μl	50μl	50μl	¥1100.00	登录查看
A-DK14232-100μl	100μl	100μl	¥2000.00	登录查看

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产品名称	PACSIN1 Rabbit Polyclonal Antibody (N-term)
英文名称	PACSIN1 Rabbit Polyclonal Antibody (N-term)
类别	抗体产品
反应种属	Human, Rat, Mouse
应用	WB, IHC-P

别名	Protein kinase C and casein kinase substrate in neurons protein 1, Syndapin-1, PACSIN1, KIAA1379
Clonality	Polyclonal
稀释度	WB 1:1000, IHC-P 1:100-500
预测分子量	51kDa
宿主	Rabbit
同种型	IgG
组织表达	Highly expressed in brain and, at much lower levels, in heart and pancreas.
细胞定位	Cytoplasm. Cell projection. Cell junction, synapse, synaptosome. Cell projection, ruffle membrane. Membrane; Peripheral membrane protein. Cytoplasmic vesicle membrane; Peripheral membrane protein. Cell junction, synapse. Cytoplasm, cytosol. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Note=Colocalizes with MAPT in axons. In primary neuronal cultures, present at a high level in presynaptic nerve terminals and in the cell body. Colocalizes with DNM1 at vesicula r structures in the cell body and neurites (By similarity). Associates with membranes via its F-BAR domain.
Human Gene ID	NP_001186512.1;NP_065855.1
特异性	This PACSIN1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide be tween 8-38 amino acids from the N-terminal region of human PACSIN1.
纯化	Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
背景介绍	Protein kinases are enzymes that transfer a phosphate group from a phosphate donor, generally the g phosphate of ATP, onto an acceptor amino acid in a substrate protein. By this basic mechanism, protein kinases mediate most of the signal transduc tion in eukaryotic cells, regulating cellular metabolism, transcription, cell cycle progression, cytoskeletal rearrangement and cell movement, apoptosis, and differentiation. With more than 500 gene products, the protein kinase family is one of t he largest families of proteins in eukaryotes. The family has been classified in 8 major groups based on sequence compariso n of their tyrosine (PTK) or serine/threonine (STK) kinase catalytic domains. The STE group (homologs of yeast Sterile 7, 1 1, 20 kinases) consists of 50 kinases related to the mitogen-activated protein kinase (MAPK) cascade families (Ste7/MAP2K, Ste11/MAP3K, and Ste20/MAP4K). MAP kinase cascades, consisting of a MAPK and one or more upstream regulatory kinases (MAPKK s) have been best characterized in the yeast pheromone response pathway. Pheromones bind to Ste cell surface receptors and activate yeast MAPK pathway.

Western blot analysis of lysates from Daudi cell line, human brain, human pancrease, human heart tissue (from left to right), using PACSIN1 Antibody (G23). 569 was diluted at 1:1000 at each lane. A goat anti-rabbit IgG H&L(HRP) at 1:10000 dilution was use

Western blot analysis of lysates from Daudi cell line, human heart and pancreas tissue lysate(from left to right), using PACSIN1 Antibody (G23). 569 was diluted at 1:1000 at each lane. A goat anti-rabbit IgG H&L(HRP) at 1:10000 dilution was used as the se

Western blot analysis of anti-PACSIN1 Pab in HL-60 cell line lysate. PACSIN1 (arrow) was detected using purified Pab. Secondary HRP-anti-rabbit was used for signal visualization with chemiluminescence.

Western blot analysis of anti-PACSIN1 Pab in mouse brain tissue lysate . PACSIN1 (arrow) was detected using purified Pab. Secondary HRP-anti-rabbit was used for signal visualization with chemiluminescence.

Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clin