别名
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Stromal cell-derived factor 1, SDF-1, 12-O-tetradecanoylphorbol 13-acetate repressed protein 1, TPAR1, C-X-C motif chemo
kine 12, Pre-B cell growth-stimulating factor, PBSF, Thymic lymphoma cell-stimulating factor, TLSF, Cxcl12, Sdf1
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组织表达
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Highest expression levels detected in kidney, liver, spleen and muscle. Isoform Alpha is expressed ubiquitously but at v
arying levels, while isoform Beta displays tissue-specific expression, with expression detected in kidney, liver, heart,
spleen and m
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背景介绍
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Chemoattractant active on T-lymphocytes, monocytes, but not neutrophils. Activates the C-X-C chemokine receptor CXCR4 to in
duce a rapid and transient rise in the level of intracellular calcium ions and chemotaxis. Also binds to atypical chemokine
receptor ACKR3, which activates the beta-arrestin pathway and acts as a scavenger receptor for SDF-1. Acts as a positive r
egulator of monocyte migration and a negative regulator of monocyte adhesion via the LYN kinase. Stimulates migration of mo
nocytes and T- lymphocytes through its receptors, CXCR4 and ACKR3, and decreases monocyte adherence to surfaces coated with
ICAM-1, a ligand for beta-2 integrins. SDF1A/CXCR4 signaling axis inhibits beta-2 integrin LFA-1 mediated adhesion of mono
cytes to ICAM-1 through LYN kinase. Plays a protective role after myocardial infarction. Induces down-regulation and intern
alization of ACKR3 expressed in various cells (By similarity). Has several critical functions during embryonic development;
required for B-cell lymphopoiesis, myelopoiesis in bone marrow and heart ventricular septum formation.
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