别名
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Polycomb complex protein BMI-1, Polycomb group RING finger protein 4, Bmi1, Bmi-1, Pcgf4
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背景介绍
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Component of a Polycomb group (PcG) multiprotein PRC1- like complex, a complex class required to maintain the transcription
ally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remod
eling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably
changed in its expressibility. In the PRC1 complex, it is required to stimulate the E3 ubiquitin-protein ligase activity of
RNF2/RING2 (By similarity).
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