|
产品名称 |
MB21D1 (18Q12) Mouse Monoclonal Antibody |
|
英文名称 |
MB21D1 (18Q12) Mouse Monoclonal Antibody |
|
类别 |
抗体产品 |
|
反应种属 |
Human |
|
应用 |
WB |
|
别名 |
Cyclic GMP-AMP synthase, cGAMP synthase, cGAS, h-cGAS, 2.7.7.86, Mab-21 domain-containing protein 1, MB21D1, C6orf150 |
|
Clonality |
Monoclonal |
|
稀释度 |
WB 1:1000 |
|
预测分子量 |
59kDa |
|
同种型 |
IgG1,κ |
|
组织表达 |
Expressed in the monocytic cell line THP1. |
|
细胞定位 |
Cell membrane; Peripheral membrane protein. Cytoplasm, cytosol. Nucleus. Note=In resting conditions, localizes at the ce ll membrane as a peripheral membrane protein by binding to phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) (PubMed :30827685). Localization at the cell membrane is required to limit the recognition of self-DNA (PubMed:30827685). Follow ing detection of double-stranded DNA (dsDNA), released from the cell membrane into the cytosol in order to signal (PubMe d:30827685). Upon transfection with dsDNA forms punctate structures that co-localize with DNA and Beclin-1 (BECN1) (PubM ed:26048138). Phosphorylation at Tyr-215 promotes cytosolic retention; translocates into the nucleus following dephospho rylation (PubMed:30356214). |
|
特异性 |
This MB21D1 antibody is generated from a mouse immunized with a KLH conjugated synthetic peptide bet ween 1-185 amino acids from human MB21D1. |
|
背景介绍 |
Nucleotidyltransferase that catalyzes the formation of cyclic GMP-AMP (cGAMP) from ATP and GTP. Catalysis involves both the |
 Mouse Monoclonal Antibody.jpg)
All lanes : Anti-MB21D1 Antibody at 1:1000 dilution Lane 1: Hela whole cell lysate Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Mouse IgG/A/M(H/L), Peroxidase conjugated at 1/2000 dilution. Observed band size : 62kDa Blocking/Dilution buffer: 5
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 Mouse Monoclonal Antibody.jpg)
资料/datasheet
