别名
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Interleukin-1 receptor-like 2, IL-36 receptor, IL-36R, Interleukin-1 receptor-related protein 2, IL-1Rrp2, IL1R-rp2, IL1
RL2, IL1RRP2
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Clonality
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Polyclonal
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稀释度
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WB 1:8000, FCM 1:25
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预测分子量
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65kDa
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宿主
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Rabbit
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Human Gene ID
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NP_001446.1;NP_963853.1
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运输及保存条件
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Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
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同种型
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IgG
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功能
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Receptor for interleukin-36 (IL36A, IL36B and IL36G). After binding to interleukin-36 associates with the coreceptor IL1RAP
to form the interleukin-36 receptor complex which mediates interleukin-36- dependent activation of NF-kappa-B, MAPK and ot
her pathways (By similarity). The IL-36 signaling system is thought to be present in epithelial barriers and to take part i
n local inflammatory response; it is similar to the IL-1 system. Seems to be involved in skin inflammatory response by indu
ction of the IL-23/IL-17/IL-22 pathway.
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组织表达
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Expressed in synovial fibroblasts and articular chondrocytes. Expressed in keratinocytes and monocyte-derived dendritic
cells. Expressed in monocytes and myeloid dendritic cells; at protein level.
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细胞定位
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Membrane; Single-pass type I membrane protein
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特异性
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This IL1RL2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 257-286 amino a
cids from the Central region of human IL1RL2.
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背景介绍
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The protein encoded by this gene is a member of the interleukin 1 receptor family. An experiment with transient gene expres
sion demonstrated that this receptor was incapable of binding to interleukin 1 alpha and interleukin 1 beta with high affin
ity. This gene and four other interleukin 1 receptor family genes, including interleukin 1 receptor, type I (IL1R1), interl
eukin 1 receptor, type II (IL1R2), interleukin 1 receptor-like 1 (IL1RL1), and interleukin 18 receptor 1 (IL18R1), form a c
ytokine receptor gene cluster in a region mapped to chromosome 2q12. [provided by RefSeq].
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