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IL1RL2 Rabbit Polyclonal Antibody (Center)
A-DK15851
IL1RL2 Rabbit Polyclonal Antibody (Center)
货号 纯度 规格 目录价 会员价 库存 数量 购买
A-DK15851-50μl 50μl 50μl ¥1100.00 登录查看
A-DK15851-100μl 100μl 100μl ¥2000.00 登录查看
产品详情

产品名称

IL1RL2 Rabbit Polyclonal Antibody (Center)

英文名称

IL1RL2 Rabbit Polyclonal Antibody (Center)

类别

抗体产品

反应种属

Human

应用

WB, FCM

别名

Interleukin-1 receptor-like 2, IL-36 receptor, IL-36R, Interleukin-1 receptor-related protein 2, IL-1Rrp2, IL1R-rp2, IL1

RL2, IL1RRP2

Clonality

Polyclonal

稀释度

WB 1:8000, FCM 1:25

预测分子量

65kDa

宿主

Rabbit

Human Gene ID

 NP_001446.1;NP_963853.1

运输及保存条件

Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

同种型

IgG

功能

Receptor for interleukin-36 (IL36A, IL36B and IL36G). After binding to interleukin-36 associates with the coreceptor IL1RAP
 to form the interleukin-36 receptor complex which mediates interleukin-36- dependent activation of NF-kappa-B, MAPK and ot
her pathways (By similarity). The IL-36 signaling system is thought to be present in epithelial barriers and to take part i
n local inflammatory response; it is similar to the IL-1 system. Seems to be involved in skin inflammatory response by indu
ction of the IL-23/IL-17/IL-22 pathway.

组织表达

Expressed in synovial fibroblasts and articular chondrocytes. Expressed in keratinocytes and monocyte-derived dendritic

cells. Expressed in monocytes and myeloid dendritic cells; at protein level.

细胞定位

Membrane; Single-pass type I membrane protein

特异性

This IL1RL2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 257-286 amino a

cids from the Central region of human IL1RL2.

背景介绍

The protein encoded by this gene is a member of the interleukin 1 receptor family. An experiment with transient gene expres
sion demonstrated that this receptor was incapable of binding to interleukin 1 alpha and interleukin 1 beta with high affin
ity. This gene and four other interleukin 1 receptor family genes, including interleukin 1 receptor, type I (IL1R1), interl
eukin 1 receptor, type II (IL1R2), interleukin 1 receptor-like 1 (IL1RL1), and interleukin 18 receptor 1 (IL18R1), form a c
ytokine receptor gene cluster in a region mapped to chromosome 2q12. [provided by RefSeq].

                           

Overlay histogram showing K562 cells stained with 347 (green line). The cells were fixed with 2% paraformaldehyde (10 min). The cells were then icubated in 2% bovine serum albumin to block non-specific protein-protein interactions followed by the antibody

                           

All lanes : Anti-IL1RL2 Antibody (Center) at 1:8000 dilution Lane 1: HL-60 whole cell lysate Lane 2: U-87 MG whole cell lysate Lane 3: K562 whole cell lysate Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated                             

 

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