| 产品介绍 |
Safinamide (EMD 1195686; FCE 26743)是可逆的MAO-B抑制剂，IC50为98 nM，比对MAO-A的抑制性高5918倍。 |
| 别名 |
沙芬酰胺;(S)-2-[[4-[(3-氟苯甲基)氧]苯甲基]氨基]丙酰胺;EMD 1195686;FCE 26743;EMD-1195686;EMD1195686;FCE-26743;2(S)-[4-(3-Fluorobenzyloxy)benzylamino]propionamide |
| 生化机理 |
Safinamide is a highly selective and reversible monoamine oxidase type B (MAO-B) inhibitor that increases neostriatal dopamine concentration. In addition, Safinamide is voltage-dependent sodium and calcium channel blocker. Safinamide appears to bind to the batrachotoxin-sensitive site 2 of the voltage-sensitive sodium channels. Safinamide blocks N and L-type calcium channels and inhibits glutamate and aspartate release from synaptic terminals. |
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