|
产品名称 |
HuR / ELAVL1 (6W9) Rabbit Monoclonal Antibody |
|
英文名称 |
HuR / ELAVL1 (6W9) Rabbit Monoclonal Antibody |
|
类别 |
抗原抗体 |
|
反应种属 |
Human,Mouse,Rat |
|
应用 |
WB,IHC-P,IF-ICC,FCM,IP,IF-P |
|
别名 |
HUR; Hua; MelG; ELAV1; |
|
Clonality |
Monoclonal |
|
存储缓冲液 |
Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% New type preservative N and 0.05% BSA. |
|
免疫原 |
A synthetic peptide of human HuR/ELAVL1 |
|
稀释度 |
WB 1:1000, IHC-P/IF-P 1:100, IF-ICC 1:100, FCM 1:20-1:100, IP 1:20 |
|
参考分子量 |
36kDa |
|
预测分子量 |
36kDa |
|
运输及保存条件 |
20°C/1 year |
|
Human Gene ID |
1994 |
|
基因名称 |
ELAVL1 |
|
蛋白名称 |
HUR |
|
宿主 |
Rabbit |
|
同种型 |
LgG |
|
组织表达 |
Ubiquitous. Detected in brain, liver, thymus and muscle. |
|
细胞定位 |
Cytoplasm. Nucleus. Cytoplasm, Stress granule {ECO:0000250|UniProtKB:P70372}. Note=Translocates into the cytoplasm g phosphorylation by MAPKAPK2 (PubMed:) Likewise, phosphorylation by PRKCD promotes translocation from the nucleus into the cytoplasm, where it is associated with free and cytoskeleton-bound polysomes (PubMed:18285462).Localizes to the st ress granules in the presence of PLEKHN1 (By similarity) {ECO:0000250|UniProtKB:P70372, ECO:0000269|PubMed:, ECO:00 00269|PubMed:18285462} |
|
注意事项 |
HuR / ELAVL1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
|
功能 |
RNA-binding protein that binds to the 3'-UTR region of mRNAs and increases their stability (PubMed:14517288, PubMed:, |
 Rabbit Monoclonal Antibody.jpg)
Western blot analysis of HuR / ELAVL1 expression in (1) Jurkat cell lysate; (2) Mouse heart lysate; (3) Rat spleen lysate.
Involved in 3'-UTR ARE-mediated MYC stabilization. Binds avidly to the AU-rich element in FOS and IL3/interleukin-3 mRNAs. In the case of the FOS AU-rich element, HUR binds to a core element of 27 nucleotides that contain AUUUA, AUUUUA and AUUUUUA motifs.
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 Rabbit Monoclonal Antibody.jpg)
资料/datasheet
