别名
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Na+/Ca2+ exchanger; NCX1; SLC8A1;
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Clonality
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Monoclonal
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存储缓冲液
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Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% New type preservative N and 0.05% BSA.
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免疫原
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A synthetic peptide of human NCX1
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稀释度
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WB 1:1000
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参考分子量
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109kDa
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预测分子量
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109kDa
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运输及保存条件
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20°C/1 year
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Human Gene ID
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6546
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基因名称
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SLC8A1
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蛋白名称
|
NCX1
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宿主
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Rabbit
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同种型
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LgG
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组织表达
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Detected primarily in heart and at lower levels in brain (PubMed:1374913). Expressed in cardiac sarcolemma, brain, kidney,
liver, pancreas, skeletal muscle, placenta and lung (PubMed:1476165)
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细胞定位
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Cell membrane; Multi-pass membrane protein
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注意事项
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NCX1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
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功能
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Mediates the exchange of one Ca(2+) ion against three to four Na(+) ions across the cell membrane, and thereby contributes to
the regulation of cytoplasmic Ca(2+) levels and Ca(2+)-dependent cellular processes (PubMed:1374913, , PubMed
:1476165). Contributes to Ca(2+) transport during excitation-contraction coupling in muscle. In a first phase, voltage-gated
channels mediate the rapid increase of cytoplasmic Ca(2+) levels due to release of Ca(2+) stores from the endoplasmic reticul
um. SLC8A1 mediates the export of Ca(2+) from the cell during the next phase, so that cytoplasmic Ca(2+) levels rapidly retur
n to baseline. Required for normal embryonic heart development and the onset of heart contractions.
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