|
产品名称 |
IMPDH2 (12M4) Rabbit Monoclonal Antibody |
|
英文名称 |
IMPDH2 (12M4) Rabbit Monoclonal Antibody |
|
类别 |
抗原抗体 |
|
反应种属 |
Human,Mouse,Rat |
|
应用 |
WB,IHC-P,IF-ICC,IF-P |
|
别名 |
IMPD2; IMPDH 2; IMPDH II; Impdh2; |
|
Clonality |
Monoclonal |
|
存储缓冲液 |
Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% New type preservative N and 0.05% BSA. |
|
免疫原 |
A synthetic peptide of human IMPDH2 |
|
稀释度 |
WB 1:1000, IHC-P/IF-P 1:100-1:200, IF-ICC 1:100-1:200 |
|
参考分子量 |
56kDa |
|
预测分子量 |
56kDa |
|
运输及保存条件 |
20°C/1 year |
|
Human Gene ID |
3615 |
|
基因名称 |
IMPDH2 |
|
蛋白名称 |
IMPD2 |
|
宿主 |
Rabbit |
|
同种型 |
LgG |
|
组织表达 |
IMPDH1 is the main species in normal leukocytes and IMPDH2 predominates over IMPDH1 in the tumor |
|
细胞定位 |
Cytoplasm. Nucleus. Cytoplasm, cytosol. Note=Can form fiber-like subcellular structures termed 'cytoophidia' in response to intracellular guanine- nucleotide depletion. |
|
注意事项 |
IMPDH2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
|
功能 |
Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limit ing step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell g rowth (PubMed:7903306, PubMed:7763314). Could also have a single-stranded nucleic acid-binding activity and could play a ro le in RNA and/or DNA metabolism (PubMed:14766016). It may also have a role in the development of malignancy the growth progression of some tumors. |
 Rabbit Monoclonal Antibody.jpg)
Western blot detection of IMPDH2 in Hela,A549,HL-60,U2OS,C6 using IMPDH2 antibody(1:1000 diluted)
Rate limiting enzyme in the de novo synthesis of guanine nucleotides and therefore is involved in the regulation of cell growth. It may also have a role in the development of malignancy and the growth progression of some tumors.
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 Rabbit Monoclonal Antibody.jpg)
资料/datasheet
