Integrin beta 3 / CD61 (6R14) Rabbit Monoclonal Antibody

生化试剂盒
辅酶Ⅰ系列谷胱甘肽系列维生素C代谢系列氧化与抗氧化系列氮代谢系列氨基酸代谢系列酯酶系列氧化磷酸化系列三羧酸循环系列乙醛酸循环系列糖酵解系列蛋白酶系列脂肪酸代谢系列蔗糖系列糖代谢系列 P451系列离子系列土壤系列信号系列蛋白含量测定系列糖异生系列糖原系列维生素系列光合作用系列植物激素系列辅酶Ⅱ系列 P457系列蛋白酶活性系列酯酶活性系列
ELISA试剂盒
Mouse/小鼠Elisa试剂盒 Human/人Elisa试剂盒 Rabbit/兔Elisa试剂盒 Rat/大鼠Elisa试剂盒 Porcine/猪Elisa试剂盒其它种属ELISA试剂盒农药残留检测农药残留金标法
抗体、蛋白与多肽
常规抗体多克隆抗体二抗标记二抗标记蛋白质与多肽动物血清及球蛋白重组蛋白
细胞生物学
人细胞系小鼠细胞系大鼠细胞系猪细胞系猴细胞系仓鼠细胞系其它细胞系原代细胞原代细胞永生化细胞培养基细胞培养添加剂细胞培养耗材胎牛血清正常细胞系
RT-PCR试剂盒
荧光pcr 荧光定量PCR
PCR相关试剂
提取试剂盒核酸纯化相关试剂 PCR及RT-PCR相关 DNA分子量标准克隆载体及相关产品恒温扩增系列 PCR相关其他DNA/RNA聚合酶 RNA相关产品 miRNA检测系列克隆相关蛋白相关核酸酶系列核酸修饰酶系列
标准溶液
抗生素细胞培养细胞染色培养基细胞组分分离细胞检测细胞其他骨组织染色结缔染色脱钙液脱水剂酶类染色固定液碳水染色 HE染色指示剂色素染色神经染色脂类染色微生物染色核酸染色金属及盐染色染色其他免疫组化免疫检测核酸电泳感受态制备 DNA溶液核酸提取核酸杂交 PCR相关 RNA溶液核酸检测载体菌种核酸其他滴定液标准物质蛋白电泳酶抑制剂表达纯化蛋白提取蛋白检测免疫印迹蛋白其他常规其他动物实验常规其他洗涤液抗凝剂消毒剂抑菌剂缓冲液比色液生化检测
血清血浆
血清血浆

产品编号： A-DK11109

英文名称： Integrin beta 3 / CD61 (6R14) Rabbit Monoclonal Antibody

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货号	纯度	规格	目录价	会员价	库存	数量	购买
A-DK11109-50µl	50µl	50µl	¥1200.00	登录查看
A-DK11109-100µl	100µl	100µl	¥2200.00	登录查看

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资料/datasheet

产品名称	Integrin beta 3 / CD61 (6R14) Rabbit Monoclonal Antibody
英文名称	Integrin beta 3 / CD61 (6R14) Rabbit Monoclonal Antibody
类别	抗原抗体
反应种属	Human,Mouse,Rat
应用	WB,IP

别名	BDPLT16; BDPLT2; CD61; GP3A; GPIIIa; HPA 1; HPA 4; Integrin beta 3 (platelet glycoprotein IIIa antigen CD61); Integrin beta chain beta 3; Integrin beta-3; ITGB3; NAIT; Platelet fibrinogen receptor beta subunit; Platelet glycoprotein IIIa; PTP;
Clonality	Monoclonal
存储缓冲液	Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% New type preservative N and 0.05% BSA.
免疫原	A synthetic peptide of human Integrin beta 3
稀释度	WB 1:1000, IP 1:20
参考分子量	100kDa
预测分子量	87kDa
运输及保存条件	20°C/1 year
Human Gene ID	3690
基因名称	ITGB3
蛋白名称	GP3A
宿主	Rabbit
同种型	LgG
组织表达	Isoform beta-3A and isoform beta-3C are widely expressed. Isoform beta-3A is specifically expressed in osteoblast cells; isoform beta-3C is specifically expressed in prostate and testis
细胞定位	Cell membrane; Single-pass type I membrane protein. Cell projection, lamellipodium membrane. Cell junction, focal adhesi on. Cell junction, synapse, postsynaptic cell membrane {ECO:0000250\|UniProtKB:O54890}; Single-pass type I membrane prote in {ECO:0000250\|UniProtKB:O54890} Cell junction, synapse {ECO:0000250\|UniProtKB:O54890}
注意事项	Integrin beta 3 / CD61 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
功能	Integrin alpha-V/beta-3 (ITGAV:ITGB3) is a receptor for cytotactin, fibronectin, laminin, matrix metalloproteinase-2, osteo pontin, osteomodulin, prothrombin, thrombospondin, vitronectin and von Willebrand factor. Integrin alpha-IIb/beta-3 (ITGA2B :ITGB3) is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. Integrins alph a-IIb/beta-3 and alpha- V/beta-3 recognize the sequence R-G-D in a wide array of ligands. Integrin alpha-IIb/beta-3 recogni zes the sequence H-H-L-G-G-G-A-K-Q-A- G-D-V in fibrinogen gamma chain. Following activation integrin alpha- IIb/beta-3 brin gs about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial surface. Fibrinogen binding enhances SELP expression in activated platelets (B y similarity). ITGAV:ITGB3 binds to fractalkine (CX3CL1) and acts as its coreceptor in CX3CR1-dependent fractalkine signali ng (PubMed:23125415, PubMed:24789099). ITGAV:ITGB3 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ER BB signaling (PubMed:20682778). ITGAV:ITGB3 binds to FGF1 and this binding is essential for FGF1 signaling (PubMed:18441324 ). ITGAV:ITGB3 binds to FGF2 and this binding is essential for FGF2 signaling (PubMed:). ITGAV:ITGB3 binds to IGF1 and this binding is essential for IGF1 signaling (PubMed:19578119). ITGAV:ITGB3 binds to IGF2 and this binding is essential for IGF2 signaling (PubMed:28873464). ITGAV:ITGB3 binds to IL1B and this binding is essential for IL1B signaling (PubMed:2 9030430). ITGAV:ITGB3 binds to PLA2G2A via a site (site 2) which is distinct from the classical ligand-binding site (site 1 ) and this induces integrin conformational changes and enhanced ligand binding to site 1 (PubMed:18635536, PubMed:25398877) . ITGAV:ITGB3 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1 (PubMed:12807887 ). In brain, plays a role in synaptic transmission and plasticity. Involved in the regulation of the serotonin neurotransmi ssion, is required to localize to specific compartments within the synapse the serotonin receptor SLC6A4 and for an appropr iate reuptake of serotonin. Controls excitatory synaptic strength by regulating GRIA2-containing AMPAR endocytosis, which a ffects AMPAR abundance and composition (By similarity). ITGAV:ITGB3 act as a receptor for CD40LG (PubMed:31331973).

Western blot analysis of Integrin beta 3 / CD61 expression in U-87 MG cell lysate.

Western blot analysis of extracts from Rat heart tissue using at 1:1000.

Western blot analysis of extracts from HUVEC cells using at 1:1000.

In brain, plays a role in synaptic transmission and plasticity. Involved in the regulation of the serotonin neurotransmission, is required to localize to specific compartments within the synapse the serotonin receptor SLC6A4 and for an appropriate reuptake of serotonin. Controls excitatory synaptic strength by regulating GRIA2-containing AMPAR endocytosis, which affects AMPAR abundance and composition (By similarity).