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RalA (9L18) Rabbit Monoclonal Antibody
A-DK12242
RalA (9L18) Rabbit Monoclonal Antibody
货号 纯度 规格 目录价 会员价 库存 数量 购买
A-DK12242-50µl 50µl 50µl ¥1200.00 登录查看
A-DK12242-100µl 100µl 100µl ¥2200.00 登录查看
产品详情

产品名称

RalA (9L18) Rabbit Monoclonal Antibody

英文名称

RalA (9L18) Rabbit Monoclonal Antibody

类别

抗原抗体

反应种属

Human

应用

WB,IHC-P,IHC-F

别名

Ral a; RAL; RALA;

Clonality

Monoclonal

存储缓冲液

Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% New type preservative N and 50% glycerol. Store at +4°C

short term. Store at -20°C long term. Avoid freeze / thaw cycle.

稀释度

WB 1:1000-1:2000,IHC-P/IHC-F 1:100-1:200

Human Gene ID

5898

预测分子量

24kDa

参考分子量

25kDa

蛋白名称

RAL

基因名称

RALA

宿主

Rabbit

同种型

LgG

细胞定位

Cell membrane; Lipid-anchor; Cytoplasmic side. Cleavage furrow. Midbody, Midbody ring. Mitochondrion. Note=Predominantly

at the cell surface in the absence of LPA. In the presence of LPA, colocalizes with LPAR1 and LPAR2 in endocytic vesicl

es (PubMed:19306925). May colocalize with CNTRL/centriolin at the midbody ring (PubMed:16213214). However, localization

at the midbody at late cytokinesis was not confirmed (PubMed:18756269). Relocalizes to the mitochodrion during mitosis w

here it regulates mitochondrial fission (PubMed:21822277)

注意事项

RalA Antibody is for research use only and not for use in diagnostic or therapeutic procedures.

功能

 Multifunctional GTPase involved in a variety of cellular processes including gene expression, cell migration, ce
ll proliferation, oncogenic transformation and membrane trafficking. Accomplishes its multiple functions by interacting wit
h distinct downstream effectors. Acts as a GTP sensor for GTP-dependent exocytosis of dense core vesicles. The RALA-exocyst
complex regulates integrin- dependent membrane raft exocytosis and growth signaling (PubMed:20005108). Key regulator of LP
AR1 signaling and competes with GRK2 for binding to LPAR1 thus affecting the signaling properties of the receptor. Required
for anchorage-independent proliferation of transformed cells (PubMed:19306925). During mitosis, supports the stabilization
and elongation of the intracellular bridge between dividing cells. Cooperates with EXOC2 to recruit other components of th
e exocyst to the early midbody (PubMed:18756269). During mitosis, also controls mitochondrial fission by recruiting to the
mitochondrion RALBP1, which mediates the phosphorylation and activation of DNM1L by the mitotic kinase cyclin B-CDK1.

                         

Western blot analysis of RalA in MCF7 cell lysate.

Multifuntional GTPase involved in a variety of cellular processes including gene expression, cell migration, cell proliferation, oncogenic transformation and membrane trafficking. Accomplishes its multiple functions by interacting with distinct downstream effectors.

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