别名
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Farnesyl pyrophosphate synthase, FPP synthase, FPS, (2E,6E)-farnesyl diphosphate synthase, Dimethylallyltranstransferase
, Farnesyl diphosphate synthase, Geranyltranstransferase, FDPS, FPS, KIAA1293
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背景介绍
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This gene encodes an enzyme that catalyzes the production of geranyl pyrophosphate and farnesyl pyrophosphate from isope
ntenyl pyrophosphate and dimethylallyl pyrophosphate. The resulting product, farnesyl pyrophosphate, is a key intermedia
te in cholesterol and sterol biosynthesis, a substrate for protein farnesylation and geranylgeranylation, and a ligand o
r agonist for certain hormone receptors and growth receptors. Drugs that inhibit this enzyme prevent the post-translatio
nal modifications of small GTPases and have been used to treat diseases related to bone resorption. Multiple pseudogenes
have been found on chromosomes 1, 7, 14, 15, 21 and X. Multiple transcript variants encoding different isoforms have be
en found for this gene.
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