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Mouse Runx1 Rabbit Polyclonal Antibody (C-term)
A-DK14832
Mouse Runx1 Rabbit Polyclonal Antibody (C-term)
货号 纯度 规格 目录价 会员价 库存 数量 购买
A-DK14832-50μl 50μl 50μl ¥1100.00 登录查看
A-DK14832-100μl 100μl 100μl ¥2000.00 登录查看
产品详情

产品名称

Mouse Runx1 Rabbit Polyclonal Antibody (C-term)

英文名称

Mouse Runx1 Rabbit Polyclonal Antibody (C-term)

类别

抗体产品

反应种属

Human, Rat, Mouse

应用

WB

别名

Runt-related transcription factor 1, Acute myeloid leukemia 1 protein, Core-binding factor subunit alpha-2, CBF-alpha-2,

Oncogene AML-1, Polyomavirus enhancer-binding protein 2 alpha B subunit, PEA2-alpha B, PEBP2-alpha B, SL3-3 enhancer fa

ctor 1 alpha B

Clonality

Polyclonal

稀释度

WB 1:2000

预测分子量

49kDa

宿主

Rabbit

同种型

IgG

组织表达

Isoform 4 is expressed at high levels in thymus, spleen and T-cell lines and at lower levels in myeloid cell lines and n

onhematopoietic cells. Isoform 5 is expressed ubiquitously in lumbar vertebrae, brain, kidney, heart, muscle, ovary and

osteoblast-li

细胞定位

Nucleus.

特异性

This Mouse Runx1 antibody is generated from a rabbit immunized with a KLH conjugated synthetic pepti

de between 305-339 amino acids from the C-terminal region of Mouse Runx1.

背景介绍

CBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyom
avirus enhancer, T-cell receptor enhancers, LCK, IL-3 and GM-CSF promoters. Essential for the development of normal hematop
oiesis. Isoform 4 shows higher binding activities for target genes and binds TCR-beta-E2 and RAG-1 target site with threefo
ld higher affinity than other isoforms. It is less effective in the context of neutrophil terminal differentiation. Acts sy
nergistically with ELF4 to transactivate the IL-3 promoter and with ELF2 to transactivate the BLK promoter. Inhibits KAT6B-
dependent transcriptional activation (By similarity).

                           

Anti-Runx1 Antibody (C-term)at 1:2000 dilution + SW620 whole cell lysates Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution Predicted band size : 49 kDa Blocking/Dilution buffer: 5% NFDM/T

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