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产品名称 |
NPPA (6M7) Mouse Monoclonal Antibody |
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英文名称 |
NPPA (6M7) Mouse Monoclonal Antibody |
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类别 |
抗体产品 |
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反应种属 |
Mouse |
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应用 |
WB |
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别名 |
Natriuretic peptides A, CDD-ANF, Cardiodilatin, CDD, Cardiodilatin-related peptide, CDP, Prepronatriodilatin, Atrial nat riuretic factor, ANF, Atrial natriuretic peptide, ANP, NPPA, ANP, PND |
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Clonality |
Monoclonal |
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稀释度 |
WB 1:2000 |
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预测分子量 |
16kDa |
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同种型 |
IgG1,κ |
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组织表达 |
[Urodilatin]: Detected in the kidney distal tubular cells (at protein level) (PubMed:9794555, PubMed:8384600). Present i n urine (at protein level) (PubMed:2972874, PubMed:9794555, PubMed:8351194, PubMed:8779891). |
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细胞定位 |
[Long-acting natriuretic peptide]: Secreted. Note=Detected in blood. [Kaliuretic peptide]: Secreted. Note=Detected in bl ood [Atrial natriuretic peptide]: Secreted. Perikaryon. Cell projection. Note=Detected in blood (PubMed:8351194, PubMed: 8779891, PubMed:7955907, PubMed:8653797, PubMed:15741263, PubMed:18835931, PubMed:2532366, PubMed:7984506). Detected in urine in one study (PubMed:8351194). However, in another study, was not detected in urine (PubMed:7984506). Detected in cytoplasmic bodies and neuronal processes of pyramidal neurons (layers II-VI) (PubMed:30534047) Increased secretion in r esponse to the vasopressin AVP (By similarity) Likely to be secreted in response to an increase in atrial pressure or at rial stretch (PubMed:2532366). In kidney cells, secretion increases in response to activated guanylyl cyclases and incre ased intracellular cAMP levels (PubMed:9893117). Plasma levels increase 15 mins after a high-salt meal, and decrease bac k to normal plasma levels 1 hr later (PubMed:8779891). {ECO:0000250|UniProtKB:P01161, ECO:0000269|PubMed:15741263, ECO:0 000269|PubMed:18835931, ECO:0000269|PubMed:2532366, ECO:0000269|PubMed:30534047, ECO:0000269|PubMed:7955907, ECO:0000269 |PubMed:7984506, ECO:0000269|PubMed:8351194, ECO:0000269|PubMed:8653797, ECO:0000269|PubMed:8779891, ECO:0000269|PubMed: 9893117} |
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特异性 |
This NPPA antibody is generated from a mouse immunized with a recombinant protein of human NPPA. |
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背景介绍 |
Hormone playing a key role in cardiovascular homeostasis through regulation of natriuresis, diuresis, and vasodilation. Als |
 Mouse Monoclonal Antibody.jpg)
Anti-NPPA Antibody at 1:2000 dilution + mouse heart lysate Lysates/proteins at 20 µg per lane. Secondary Goat Anti-mouse IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 17 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
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 Mouse Monoclonal Antibody.jpg)
资料/datasheet
