Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
同种型
IgG
特异性
This KLF4(S254) antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between amino acid
s from the human region of human KLF4(S254).
背景介绍
Transcription factor; can act both as activator and as repressor. Binds the 5'-CACCC-3' core sequence. Binds to the promote
r region of its own gene and can activate its own transcription. Regulates the expression of key transcription factors duri
ng embryonic development. Plays an important role in maintaining embryonic stem cells, and in preventing their differentiat
ion. Required for establishing the barrier function of the skin and for postnatal maturation and maintenance of the ocular
surface. Involved in the differentiation of epithelial cells and may also function in skeletal and kidney development. Cont
ributes to the down-regulation of p53/TP53 transcription.