
产品名称
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HNRPAB Rabbit Polyclonal Antibody (N-term)
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英文名称
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HNRPAB Rabbit Polyclonal Antibody (N-term)
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类别
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抗体产品
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反应种属
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Human
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应用
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IHC-P, IF-ICC, WB
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别名
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Heterogeneous nuclear ribonucleoprotein A/B, hnRNP A/B, APOBEC1-binding protein 1, ABBP-1, HNRNPAB, ABBP1, HNRPAB
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Clonality
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Polyclonal
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稀释度
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WB 1:1000, IHC-P 1:100-500, IF-ICC 1:10-50
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预测分子量
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36kDa
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宿主
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Rabbit
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Human Gene ID
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NP_005219.2;NP_958439.1;NP_958440.1;NP_958441.1
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运输及保存条件
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Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
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同种型
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IgG
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功能
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Binds single-stranded RNA. Has a high affinity for G-rich and U-rich regions of hnRNA. Also binds to APOB mRNA transcripts
around the RNA editing site.
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组织表达
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Ubiquitous.
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细胞定位
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Nucleus. Cytoplasm. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs
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特异性
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This HNRPAB antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acid
s from the N-terminal region of human HNRPAB.
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背景介绍
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This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs
are produced by RNA polymerase II and are components of the heterogeneous nuclear RNA (hnRNA) complexes. They are associate
d with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transp
ort. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hn
RNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene, which binds to one of the com
ponents of the multiprotein editosome complex, has two repeats of quasi-RRM (RNA recognition motif) domains that bind to RN
As.
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HNRPAB Antibody (N-term) western blot analysis in HepG2 cell line lysates (35ug/lane).This demonstrates the HNRPAB antibody detected the HNRPAB protein (arrow).
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HNRPAB Antibody (N-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human cervix carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the HNRPAB Antibody (N-t N
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Fluorescent confocal image of MCF-7 cell stained with HNRPAB Antibody (N-term)was used (1:400, 50 min at 37℃).Cytoplasmic actin was counterstained with Alexa Fluor® 555 (red) conjugated Phalloidin (7units/ml, 1 h at 37℃). Nuclei were counterstained with D N