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GSTM1 Rabbit Polyclonal Antibody (C-term)
A-DK16069
GSTM1 Rabbit Polyclonal Antibody (C-term)
货号 纯度 规格 目录价 会员价 库存 数量 购买
A-DK16069-50μl 50μl 50μl ¥1100.00 登录查看
A-DK16069-100μl 100μl 100μl ¥2000.00 登录查看
产品详情

产品名称

GSTM1 Rabbit Polyclonal Antibody (C-term)

英文名称

GSTM1 Rabbit Polyclonal Antibody (C-term)

类别

抗体产品

反应种属

Human, Mouse

应用

IHC-P, FCM, WB

别名

Glutathione S-transferase Mu 1, GST HB subunit 4, GST class-mu 1, GSTM1-1, GSTM1a-1a, GSTM1b-1b, GTH4, GSTM1, GST1

Clonality

Polyclonal

稀释度

WB 1:1000, IHC-P 1:100-500, FCM 1:10-50

预测分子量

26kDa

宿主

Rabbit

Human Gene ID

 NP_000169.1

运输及保存条件

Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

同种型

IgG

功能

Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Involved in the 
formation of glutathione conjugates of both prostaglandin A2 (PGA2) and prostaglandin J2 (PGJ2) (PubMed:9084911). Participa
tes in the formation of novel hepoxilin regioisomers (PubMed:21046276).

组织表达

Liver (at protein level).

细胞定位

Cytoplasm.

特异性

This GSTM1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 184-211 amino ac

ids from the C-terminal region of human GSTM1.

背景介绍

GSTM1 is a glutathione S-transferase that belongs to the mu class. The mu class of enzymes functions in the detoxification
of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress
, by conjugation with glutathione. The mu class of enzymes are organized in a gene cluster on chromosome 1p13.3 and are kno
wn to be highly polymorphic. These genetic variations can change an individual's susceptibility to carcinogens and toxins a
s well as affect the toxicity and efficacy of certain drugs.

                           

Western blot analysis of lysates from Jurkat, U251 cell line and human liver tissue (from left to right), using GSTM1 Antibody (C-term) at 1:5000 dilution was used as the secondary antibody. Lysates at 35ug per lane.

                           

Formalin-fixed and paraffin-embedded human hepatocarcinoma reacted with GSTM1 Antibody (C-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; N

                             

GSTM1 Antibody (C-term) flow cytometric analysis of MDA-MB231 cells (bottom histogram) compared to a negative control cell (top histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.                           

 

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