功能
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Proton-sensing G-protein coupled receptor couples to multiple intracellular signaling pathways, including GNAS/cAMP, GNAQ/p
hospholipase C (PLC), and GNA12/GNA13/Rho pathways (PubMed:12955148, PubMed:17462861, PubMed:22110680, PubMed:20211729). Ac
idosis-induced GPR4 activation increases paracellular gap formation and permeability of vascular endothelial cells through
the GNA12/GNA13/Rho GTPase signaling pathway (PubMed:32058960). In the brain may mediate central respiratory sensitivity to
CO(2)H(+) (By similarity).
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