背景介绍
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Myeloperoxidase (MPO) is a heme protein synthesized during myeloid differentiation that constitutes the major component of
neutrophil azurophilic granules. Produced as a single chain precursor, myeloperoxidase is subsequently cleaved into a light
and heavy chain. The mature myeloperoxidase is a tetramer composed of 2 light chains and 2 heavy chains. This enzyme produ
ces hypohalous acids central to the microbicidal activity of neutrophils. [provided by RefSeq, Nov 2014],
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功能
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catalytic activity:Cl(-) + H(2)O(2) = HOCl + 2 H(2)O.,catalytic activity:Donor + H(2)O(2) = oxidized donor + 2 H(2)O.,cofac
tor:Binds 1 calcium ion per heterodimer.,cofactor:Binds 1 heme B (iron-protoporphyrin IX) group covalently per heterodimer.
,disease:Defects in MPO are the cause of myeloperoxidase deficiency (MPD) [MIM:254600]. MPD is an autosomal recessive defec
t that results in disseminated candidiasis.,function:Part of the host defense system of polymorphonuclear leukocytes. It is
responsible for microbicidal activity against a wide range of organisms. In the stimulated PMN, MPO catalyzes the producti
on of hypohalous acids, primarily hypochlorous acid in physiologic situations, and other toxic intermediates that greatly e
nhance PMN microbicidal activity.,online information:MPO mutation db,online information:Myeloperoxidase entry,similarity:Be
longs to the peroxidase family. XPO subfamily.,subunit:Tetramer of two light chains and two heavy chains.,
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