背景介绍
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This gene is a target gene of the transcription factor tumor protein p53. The encoded protein is a nuclear phosphoprotein tha
t binds and inhibits transactivation by tumor protein p53, as part of an autoregulatory negative feedback loop. Overexpressio
n of this gene can result in excessive inactivation of tumor protein p53, diminishing its tumor suppressor function. This pro
tein has E3 ubiquitin ligase activity, which targets tumor protein p53 for proteasomal degradation. This protein also affects
the cell cycle, apoptosis, and tumorigenesis through interactions with other proteins, including retinoblastoma 1 and riboso
mal protein L5. More than 40 different alternatively spliced transcript variants have been isolated from both tumor and norma
l tissues. [provided by RefSeq, Jul 2008]
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